Fig. 11
From: Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration
Systemic administration of enzyme-responsive growth factor nanocapsules for promoting bone repair. a Illustration showing the mechanism of enzyme-responsive BMP-2 nanocapsule (n(BMP-2)) and their responsive delivery for bone fracture repair. b The distribution of BMP-2 and n(BMP-2) in bone defect site and other tissues site after intravenous injection of BMP-2 and n(BMP-2). c Comparation of the expression of alkaline phosphatase (ALP) activity of MSCs with BMP-2 or n(BMP-2) incubated (****P < 0.000 1). d Comparation of the Micro-CT images of different therapy after rat tibial fracture. e Comparation of the volume of bone tissue per volume of total tissue (BV/TV) after different therapy (**P < 0.01, ***P < 0.001). Reproduced with permission.127 Copyright 2019, Royal Society of Chemistry
