Fig. 1
From: Protein tyrosine phosphatases in skeletal development and diseases
Dynamic regulation of PYP by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). PTKs and PTPs catalyze transfer of phosphate groups between substrates. PTKs catalyze transfer of γ-phosphate from ATP to its substrates and PTPs remove the phosphate group from a phosphoprotein. PYP modulates various biological functions of many types of cells, including OCs, bone and cartilage cells, and is the most prevalent mechanism of protein regulation. Aberrant PYP due to altered expression or activity of PTKs or PTPs is associated with uncontrolled cell proliferation, differentiation, and diseases
