Fig. 8
From: Protein tyrosine phosphatases in skeletal development and diseases
Schematic diagrams illustrating signaling pathways and PTPs involved in chondrogenesis. Known signaling pathways that modulate the survival, proliferation, differentiation, and function of chondrocytes are connected by lines with an arrow or “┴” indicating a promoting or inhibiting regulatory role, respectively. In all signaling pathways, PTPs are marked in red. SOX9 is a crucial transcription factor for the differentiation of chondrocytes. Elevated SOX9 in the growth plate promotes early chondrocyte differentiation (“E” was labeled next to the line) but halts terminal differentiation and osteogenic transdifferentiation (“L” is labeled next to the line)
