Fig. 4
From: Prospects and challenges of dynamic DNA nanostructures in biomedical applications
Dynamic DNA structures based on proteins or other substances. a Schematic illustration of dynamic DNA structures based on proteins. b Synthetic process of ultralong DNA chains via RCA to obtain a 3D DNA network. c Mix of DNA chains to visualize the molecular diffusion and phase inversion during the formation of a DNA network. DNA-chain-1 and DNA-chain-2 were stained with SYBR Green II and Gel Red, respectively. d The process of capture, envelopment, and release: (1) capture, DNA-chain-1 was incubated with BMSCs for cell capture by anchoring to the aptamer Apt19S; (2) envelopment, DNA-chain-2 was added to the cell-containing DNA-chain-1 solution to trigger the formation of the DNA network; and (3) release, the DNA network can be digested by the nuclease DNase I to release BMSCs.152 Copyright 2020, American Chemical Society
