Fig. 7
From: Prospects and challenges of dynamic DNA nanostructures in biomedical applications
DNA hairpin-endowed biosensors. a Schematic illustration of a DNA tetrahedron (TDN)-based biosensor (T-probe) and its enhanced imaging of the target via HCR. The red dot indicates the Cy5 module; the white dot indicates the BHQ module. b Agarose gel electrophoresis image of the fabrication and HCR assay. c Fluorescence intensity responses of the T-probe exposed to the target at different molecular ratios. d Comparison of the reaction distance between naked DNA hairpins and the T-probe. e The time-dependent intensity of the T-probe suggests that it is a rapid sensor platform. f and g Specificity and sensitivity evaluation of the T-probe system.125 Copyright 2022, John Wiley and Sons
