Table 1 Systemic and local factors influencing osteocyte function

From: Bone remodeling: an operational process ensuring survival and bone mechanical competence

Stimuli (Systemic/Local)

Features affected (Local)

Factors released (Local/Systemic)

Final outcome (Systemic/Local)

PTH

Estrogens

1,25(OH)2D3

Irisin

Calcitonin

Senescence

TGF-β1

Pi

pO2

Life-Span

Network formation

Secretome

Mechanotrasduction

Sclerostin, DKK1, FGF23, DMP1, Phex, MEPE, Sema 3A RANKL, OPG SASPs, TGF-β1 OCN

• Bone Remodeling Balance

• Matrix Mineralization

• Perilacunocanalicular Remodeling

• Errors correction in Ca2+/P homeostasis

• Energy metabolism

• Myogenesis

• Oxidative stress

  1. Major systemic and local stimuli that influence osteocyte activity, the functions affected, the factors released upon exposure to the stimuli, and the impact on the system
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