Fig. 4
From: Current understanding of osteoarthritis pathogenesis and relevant new approaches

Lineage tracing technique. a–c Col2-expressing cells label a subpopulation of chondrocytes which could migrate to bone marrow underneath the growth plate and transdifferentiate into progenitor cells. a Col2-CreER mice were generated and bred with ROSAmT/mG reporter mice or ROSAtdTomato reporter mice. b Tamoxifen was intraperitoneally injected to the 2-week-old Col2-CreER; ROSAmT/mG mice or Col2-CreER; ROSAtdTomato mice for 5 consecutive days (1 mg per 10 g body weight) and mice were sacrificed at 4-week-old. c Col2-expressing cells were detected in articular chondrocytes, growth plate chondrocytes and cells located in bone marrow underneath the growth plate. d DNA barcoding technology was used for cell lineage tracing. Figure 4a, b256 and Fig. 4c257 were cited from our previous publications.