Fig. 1 | Bone Research

Fig. 1

From: Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis

Fig. 1

Loss of Runx1 in chondrocytes exacerbated articular cartilage damage after DMM surgery. a Western blot of knee joints from 4.5-month-old Runx1f/f (F/F) and Runx1f/f Col2α1-Cre (F/F/Δ) mice. b Safranin O (SO) staining for hip joint. c Anti-Runx1 immunohistochemistry (IHC) staining of the hip joint of 3- and 4-month-old mice. d, e Safranin O (SO) staining of the knee joint of 3-month-old mice after (d) sham and (e) DMM surgery. f Knee joint and hip joint OARSI scores of (d and e). The results are presented as the mean ± SD, n = 3, *P < 0.05, **P < 0.01

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