Fig. 2 | Bone Research

Fig. 2

From: Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis

Fig. 2

Runx1f/f Col2α1-Cre ER mice showed a spontaneous OA-like phenotype in vivo. a IF staining of anti-Runx1 in articular cartilage of 3-month-old male Runx1f/f Col2α1-Cre ER mice induced by vehicle (control) and TMX. Bar: 50 μm. b Quantification of (a). c H&E (HE) staining of 3-month-old male mice. Bar: 50 μm. d Safranin O (SO) staining of 3-month-old male mice. Bar: 50 μm. e SO staining of 4.5-month-old male mice. Bar: 100 μm. f Radiographic image of 6-month-old Runx1f/f Col2α1-Cre ER mice. The white arrow represents the osteophytes and a narrowed joint space. g, h Knee joint OARSI scores of (d and e). The results are presented as the mean ± SD, n = 4, ***P < 0.001

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