Fig. 3
Transcriptional distinction between the three differentiation trajectories of OS cells. a Differences in total GO pathway enrichment between the seven OS clusters. b Differences in the proportion of cell cycle phases in the 11 mesenchymal clusters. c Differences in gene expression between the OS-A2 and OS-B2 clusters. d Differences in gene expression between the OS-A2 and OS-C2 clusters. e Differences in expression between the OS-B2 and OS-C2 clusters. f Heatmap showing differences in the activation of pathways related to targeted therapies in OS-A2/B2/C2 clusters calculated by the GSVA method. g Heatmap showing differences in activation of pathways between the seven OS clusters. h Heatmaps of differences in single-cell copy number between the seven OS clusters and normal endovascular cells. i Heatmap showing differences in TF activity between the seven OS clusters. j TF activity in the seven OS clusters. The top 8 activated TFs were marked in each cluster
