Fig. 4
Classification of OS samples from the TARGET dataset based on the markers of the three differentiation branches of OS cells. a Venn diagram showing the similarities and differences of the calculated markers of OS-A2/B2/C2 clusters. b Heatmap showing the expression of the 44 selected marker genes of OS-A2/B2/C2 in all 29 clusters. Kaplan–Meier curves of overall survival for patients with different expression levels of total OS-A2 (c), OS-B2 (d) or OS-C2 (e) markers in OS patients from the TARGET dataset. f Consensus clustering matrices with the 44 marker genes of OS-A2/B2/C2 in TARGET OS samples for k = 3. g Heatmap showing the expression of 44 marker genes in the three clustered groups of TARGET OS samples. h Kaplan–Meier curves of overall survival for the three clustered groups of TARGET OS patients. i Heatmap showing activation differences of pathways related to targeted therapies in the three subgroups of TARGET OS samples. j Heatmap showing expression levels of genes related to targeted therapies in the three subgroups of TARGET OS samples
