Fig. 6
From: Hallmarks of peripheral nerve function in bone regeneration
Increased production of neuropeptides in bone healing. Various neuropeptides (NGF, BDNF, CGRP, SP, NPY, and Sema3A) are differentially distributed during the four corresponding phases (inflammatory, soft/cartilaginous callus, hard/bony callus, and remodeling) of bone healing with blood vessel and nerve regeneration. Cells (BMSCs, osteoblasts, macrophages, osteoclasts, and chondrocytes) listed in the relevant boxes have been identified as targets of specific neuropeptides during bone regeneration
