Fig. 5
From: Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Inactivation of Piezo1 in chondrocytes attenuates cartilage degradation and inflammation after ACLT. a Movat pentachrome-stained sections of undecalcified non-operated knee joints from control, Piezo1Col2a1cre, and Piezo2Col2a1Cre mice. Top panel: overview, scale bar: 500 µm; bottom panel: detailed view of the osteochondral unit, scale bar: 100 µm. b Movat pentachrome-stained sections of undecalcified anterior cruciate ligament transected (ACLT) knee joints from control, Piezo1Col2a1cre, and Piezo2Col2a1Cre mice. Top panel: overview, scale bar: 500 µm; bottom panel: detailed view of the osteochondral unit, scale bar: 100 µm. c Histomorphometric quantification of the OARSI score, d cartilage thickness (Cg. Th), e subchondral bone plate thickness (SCB. Th), and f synovitis score (n ≥ 8). Statistical analysis was conducted with one-way ANOVA (Tukey). *P < 0.05, **P < 0.01, ***P < 0.001
