Fig. 7
From: Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo1 expression is increased in human OA. a Representative histological images of femoral head sections stained for Piezo1 by immunohistochemistry, scale bar: 50 µm. b Quantification of Piezo1 expression in the articular cartilage (Cg), subchondral bone (ScB), and trabecular bone (TB) (n ≥ 8). c Representative images of toluidine-blue- (left) and trichrome-goldner-stained (right) sections of human osteophyte specimens. Boxes in the overview images (scale bar: 200 µm) indicate the position of the images shown at higher magnification (scale bar: 50 µm). d Histomorphometric quantification of the area of the various regions of the osteophyte rim. Cg: cartilage; EO: zones of endochondral ossification; Fib: fibrotic areas. e Representative histological images of human osteophyte sections stained for Piezo1 by immunohistochemistry, scale bar: 50 µm. f Quantification of Piezo1 expression in cartilage (Cg), zones of endochondral ossification (EO), fibrotic areas (Fib) and bone (Bo) (n ≥ 8). Statistical analysis was conducted with Student’s t test comparing control and OA samples (b), or one-way ANOVA (Tukey) (f). **P < 0.01, ***P < 0.001
