Fig. 2
From: The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice
Morphological analyses of the mice with different genotypes. a Macroscopic results. 2a1 and 2a2 show cutaneous or bony syndactyly between digits 2–4 in Q50R/WT mice forelimb (F) and hindlimb (H), respectively. 2a3 and 2a4 show truncated forelimb and central syndactyly hindlimb in Q50R/Q50R mice (red boxes marked syndactyly in Q50R/WT). b Micro CT scanning results. 2b1 show syndactyly with webbing and no distinct phalanges in Q50R/Q50R mice forelimb. 2b2 show central syndactyly and brachydactyly in the hindlimb of Q50R/Q50R mice. c Skeletal preparations of WT/WT and Q50R/Q50R at postnatal day 4(P4). d Skeletal preparations of WT/WT, Q50R/WT, and Q50R/Q50R at postnatal day 0(P0) (red arrows marked different ossification levels of phalanges between WT/WT and Q50R/WT). 2d1, 2d2, 2d4, and 2d5 show the delayed ossification of phalanges in the mice of Q50R/WT compared with the wild-type. 2d3 and 2d6 show the dysplasia and disorganization of bone and cartilage in Q50R/Q50R’s autopods
