Fig. 7
From: RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Schematic illustration of the mechanism by which RUFY4-induced endo-lysosomal trafficking promotes bone resorption in osteoclasts. The RUFY4 dimer promotes the fusion of late endosomes and lysosomes by interacting with Rab7 and LAMP2. The endo-lysosomes then move to the ruffled border and undergo exocytosis. This induces the secretion of lysosomal hydrolases such as active CTSK into the extracellular space near the bone. Consequently, resorption lacunae emerge. CTSK cathepsin K
