Fig. 4

Calcium based nanoparticles for ameliorating osteoporosis. a The calcium-aluminium layered double hydroxides (CALC) modulate osteoporosis through neutralising pH and regulating immune environment including macrophage repolarization and Treg recruitment.102 b, c The metal-poly DNA nanoparticles consisting calcium exert acidic neutralisation, calcium release and bone remineralization against osteoporosis.107 (Reprinted with copyright permissions)