Fig. 1 | Bone Research

Fig. 1

From: Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene

Fig. 1

Two distinct loci are associated with heel bone mineral density near the RUNX1 gene. a Locus Zoom plot of –Log10 P-values of individual tested variants for association with heel BMD as reported by Morris et al. 6 Colored triangles indicate linkage disequilibrium (LD) in European populations based on 1 000 G data relative to variant rs13046645. Lead variants reported by Morris et al at this locus are indicated by rs identifiers. Regions targeted for deletion in this study are indicated as del1(Δ1) and del2(Δ2); b Chromatin state segmentations from over one hundred cell and tissue types characterized by Roadmap Epigenome. Yellows and orange segments indicate putative regulatory elements based on chromatin signatures. Chromatin states for MSCs derived from H1 ESCs and osteoclasts are highlighted

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