Fig. 6
The clinical utility of CCN2 expression and knee AF. a Up: Representative images of H&E staining, Masson’s trichrome staining, and immunohistochemistry staining of both CCN2 and TGF-β of synovial tissues in the NC (n = 20) and AF (n = 10) groups. Bar = 100 μm. Down: Quantification of CVF, H-score of CCN2, and H-score of TGF-β in both groups. b Results of multiple knee-related patient-reported outcome measures in both groups showing a significant decrease in the scores in the AF group. c Correlation matrix of CVF, H-score of CCN2, H-score of TGF-β, and the knee-related patient-reported outcome measures. The lower part of the matrix showed the correlation coefficient, while the upper part showed the P-value of each pair. d Linear regression of the H-score of CCN2 and related factors (CVF, H-score of TGF-β, the Lysholm scale, IKDC scale, and KOOS scale). The correlation coefficient (R) and the P-value are shown in the images. CVF collagen volume fraction, IKDC International Knee Documentation Committee, KOOS Knee Injury and Osteoarthritis Outcome Score, ADL activities of daily living, Sport/Rec sport and recreation function, QOL knee-related quality of life, GROC Global Rating of Change Score; ** P < 0.01; *** P < 0.001; **** P < 0.000 1; ns, no significance. Data are shown as mean ± SD
