Fig. 5
From: Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
LGK974 treatment reduces bone morphometric parameters in the Sost-/- middle and inner ear. a Otic capsule region of interest highlighted in white. Representative 2D µCT images of wild type (WT) and Sost-/- otic capsules are shown on the top right. Representative 3D µCT images of WT and Sost-/- ossicles are shown below the otic capsules. b Representative 2D µCT images of the inner ear otic capsules of vehicle control and LGK974 treated mice. c Representative 3D µCT images of the middle ear ossicles of vehicle control and LGK974 treated mice. Otic capsule (d) B.Ar, (e) T.Ar (f) B.Ar/T.Ar and (g) capsule thickness of male and female Sost-/- mice treated with vehicle and LGK974. h BV, (i) bone surface (BS), (j) bone surface fraction (BS/BV) and (k) ossicle thickness of male and female treated and untreated Sost-/- mice. For all graphs, means of each group are indicated by the solid line, and upper and lower dashed lines represent quartiles. Blue and red represent vehicle and LGK974 treated groups, respectively. *P ≤ 0.05 and **P ≤ 0.01. Group sizes were n = 5 treated females, n = 6 non-treated females, n = 4 treated males and n = 5 non-treated males
