Fig. 8
From: CD47 is required for mesenchymal progenitor proliferation and fracture repair
Disruption of CD47 using a morpholino inhibits early ischemic fracture callus formation. µCT analysis of ischemic tibia fracture callus of morpholino-control ([M]Ctrl) (n = 4) and morpholino-CD47 ([M]CD47) (n = 4) at day 15 post-fracture. Each data point represents an individual mouse. a 3D reconstructions (white background with teal mineralized callus highlight) and sagittal-plane reconstruction (black background) of [M]Ctrl (left) and [M]CD47 (right) mice at day 15 post-fracture. Location of fracture (red arrowhead) is marked on the sagittal reconstructions. Callus morphology (mean ± SD) at day 15 post-fracture. b Callus volume, c Bone volume, d bone mineral content, e Tissue mineral content, f Callus length, g Bone volume fraction, h Bone mineral density, i Tissue mineral density. *P < 0.05, **P < 0.01, two-sided t test
