Fig. 6 | Bone Research

Fig. 6

From: SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis

Fig. 6

SPI1 binds to the PERK promoter and promotes its transcription. a The Co-IP assay was used to detect the interaction of SPI1 and PERK in senescent chondrocytes (n = 4). b Luciferase reporter assays were used to demonstrate the relationship between SPI1 and PERK promoter in 293T cells. c ChIP- RT-qPCR analysis confirmed the immunoprecipitation of SPI1 and BS1 (n = 4). Experiments were independently repeated three times. The data were expressed as mean ± SD. ****P < 0.000 1, versus the control group. t-test. one-way ANOVA

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