Table 4 Bone-derived factors in the reproductive system
From: Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs
Protein | Cell Type | Receptor | Model | Function | Ref. |
|---|---|---|---|---|---|
Ocn | Leydig cells of the testes gland | Gprc6a | Gprc6a−/− mice | Modulate the expression of enzymes necessary for testosterone synthesis in a manner dependent on Creb, thereby enhancing the survival of germ cells. | |
Leydig cells | Gprc6a | Ocn–/– and Gprc6a–/– male mice | Promote testosterone biosynthesis in the mouse testis | ||
Fgf23 | Oocytes | Fgfr1 | Mice 18.5 days postcoitum to 1 day postpartum | Mitigate oocyte apoptosis in the perinatal murine ovary through the activation of the p38 MAPK signaling cascade. | |
Opn | Cumulus cells and oocytes | Integrins and CD44 | In vitro experiments | Enhance cumulus cell expansion and oocyte fertilization |
