Fig. 7 | Bone Research

Fig. 7

From: AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

Fig. 7

Schematic diagram of this study. Patients in the PI group had lower KOOS scores and a higher incidence of radiological knee OA compared to the non-PI group. Mechanistically, lopinavir-induced Zmpste24 inhibition compromised nuclear membrane stability, reducing the interaction between the nuclear membrane-binding protein Usp7 and Mdm2. This disruption activated the Usp7/Mdm2/p53 pathway, accelerating cellular senescence

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