Fig. 3 | Bone Research

Fig. 3

From: Reduced somatosensory innervation alters the skeletal transcriptome at a single cell level in a mouse model of type 2 diabetes

Fig. 3

High-fat diet (HFD) feeding results in cortical and trabecular bone alterations. Normal diet (ND) or HFD feeding in C57BL/6J mice was instituted in week 4 of life, with analysis at week 16 of life. a µCT images of femoral midshaft cortical bone. b µCT quantifications of cortical area (Ct.Ar), cortical perimeter (Ct.Pm), cross-sectional thickness (Cs.Th) and polar moment of inertia (pMOI). n = 8 mice per group. c µCT images of distal femoral trabecular bone. d µCT quantifications of Bone volume per total volume (BV/TV), Trabecular thickness (Tb.Th), Trabecular number (Tb.N) and trabecular separation (Tb. Sp). n = 8 mice per group. Graphs represent average values ± 1 SD, *P < 0.05, **P < 0.01 and ***P < 0.001. Comparisons between groups were analyzed by unpaired Student’s t test

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