Table 3 Adjusted* hazards ratios and 95% confidence intervals for associations between alcohol intake and hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence, Liver Cancer Pooling Project
Type of alcohol | Hepatocellular carcinoma | Intrahepatic cholangiocarcinoma | ||||||
|---|---|---|---|---|---|---|---|---|
Non-case, N | Case, N | HR | 95% CI | Non-case, N | Case, N | HR | 95% CI | |
Any alcohol | ||||||||
Non-drinker | 3,34,649 | 342 | 1.00 | 334,649 | 79 | 1.00 | ||
Drinks/day | ||||||||
>0–<0.5 | 562,675 | 443 | 0.77 | (0.67–0.89) | 562,675 | 154 | 1.06 | (0.80–1.40) |
0.5–<1 | 126,280 | 73 | 0.57 | (0.44–0.73) | 126,280 | 33 | 1.02 | (0.67–1.54) |
1–<3 | 171,049 | 148 | 0.71 | (0.58–0.87) | 171,049 | 50 | 1.02 | (0.70–1.48) |
3–<5 | 35,851 | 67 | 1.04 | (0.79–1.36) | 35,851 | 15 | 1.24 | (0.70–2.18) |
5–<7** | 13,200 | 28 | 1.00 | (0.68–1.49) | 26,886 | 18 | 1.68 | (0.99–2.86) |
≥7 | 13,686 | 62 | 1.87 | (1.41–2.47) | — | — | — | |
p for trend*** | <0.0001 | 0.5 | ||||||
Beer | ||||||||
Non-drinker | 535,947 | 472 | 1.00 | 535,947 | 139 | 1.00 | ||
Drinks/day | ||||||||
>0–<0.5 | 435,229 | 446 | 0.84 | (0.73–0.96) | 435,229 | 133 | 0.99 | (0.77–1.27) |
0.5–<1 | 34,929 | 40 | 0.92 | (0.66–1.28) | 34,929 | 9 | 0.82 | (0.41–1.64) |
1–<3 | 38,887 | 53 | 0.86 | (0.64–1.15) | 38,887 | 11 | 0.81 | (0.43–1.52) |
3–<5** | 12,172 | 31 | 0.97 | (0.66–1.43) | 20,801 | 10 | 1.27 | (0.66–2.47) |
≥5 | 8,629 | 36 | 1.55 | (1.09–2.20) | — | — | — | |
p for trend*** | 0.001 | 0.9 | ||||||
Liquor | ||||||||
Non-drinker | 524,853 | 536 | 1.00 | 524,853 | 134 | 1.00 | ||
Drinks/day | ||||||||
>0–<0.5 | 422,325 | 362 | 0.81 | (0.70–0.93) | 422,325 | 123 | 1.08 | (0.84–1.39) |
0.5–<1 | 35,099 | 27 | 0.69 | (0.47–1.02) | 35,099 | 13 | 1.10 | (0.62–1.97) |
1–<3 | 59,608 | 88 | 1.12 | (0.89–1.41) | 59,608 | 17 | 0.88 | (0.52–1.47) |
3–<5** | 14,622 | 29 | 1.20 | (0.82–1.75) | 24,609 | 15 | 1.40 | (0.81–2.41) |
≥5 | 9,987 | 36 | 1.22 | (0.86–1.73) | ||||
p for trend*** | 0.0004 | 0.3 | ||||||
Wine | ||||||||
Non-drinker | 454,866 | 557 | 1.00 | 454,866 | 134 | 1.00 | ||
Drinks/day | ||||||||
>0–<0.5 | 478,686 | 408 | 0.74 | (0.65–0.85) | 478,686 | 120 | 0.81 | (0.63–1.05) |
0.5–<1 | 68,874 | 49 | 0.66 | (0.49–0.89) | 68,874 | 24 | 1.18 | (0.75–1.84) |
1–<2 | 42,471 | 33 | 0.67 | (0.47–0.96) | 42,471 | 13 | 0.93 | (0.52–1.66) |
≥2 | 18,453 | 30 | 1.35 | (0.93–1.96) | 18,453 | 11 | 1.82 | (0.97–3.39) |
p for trend*** | <0.0001 | 0.03 | ||||||
