Table 1 Patients’ and disease characteristics in the overall population and according to treatment groups
Overall population N (%) | Triplet + bev N (%) | Triplet + cetuximab N (%) | p | |
|---|---|---|---|---|
N = 159 | N = 103 | N = 56 | ||
Baseline characteristics | ||||
Age (range) | 60 (23–75) | 61 (23–75) | 57 (32–70) | — |
ECOG PS | ||||
0 | 152 (96) | 98 (95) | 54 (96) | |
1–2 | 7 (4) | 5 (5) | 2 (4) | 1.000 |
Sex | ||||
Male | 97 (61) | 63 (61) | 34 (61) | |
Female | 62 (39) | 40 (39) | 22 (39) | 1.000 |
Time to metastases | ||||
Synchronous | 131 (82) | 86 (83) | 45 (80) | |
Metachronous | 28 (18) | 17 (17) | 11 (20) | 0.666 |
No. of liver metastases | ||||
≥4 | 59 (37) | 42 (41) | 17 (30) | |
<4 | 93 (59) | 58 / 56 | 35 / 63 | 0.296 |
NA | 7 (4) | 3 (3) | 4 (7) | |
Primary resected | ||||
No | 39 (25) | 22 (21) | 17 (30) | |
Yes | 120 (75) | 81 (79) | 39 (70) | 0.248 |
Location of primary tumour | ||||
Right colon | 40 (25) | 31 (30) | 9 (16) | |
Left colon | 64 (40) | 40 (39) | 24 (43) | |
Extraperitoneal rectum | 52 (33) | 29 (28) | 23 (41) | 0.055 |
NA | 3 (2) | 3 (3) | 0 (0) | |
Nodal status of primary tumour | ||||
Node positive | 85 (53) | 60 (59) | 25 (45) | |
Node negative | 35 (22) | 21 (20) | 14 (25) | 0.356 |
NA | 39 (25) | 22 (21) | 17 (30) | |
Tumour size, diameter | ||||
>5 cm | 56 (35) | 38 (37) | 18 (32) | |
≤5 cm | 102 (64) | 65 (63) | 37 (67) | 0.603 |
NA | 1 (1) | 0 (0) | 1 (1) | |
Distribution of liver metastases | ||||
Bilobar | 96 (60) | 63 (61) | 33 (60) | |
Unilobar | 54 (34) | 32 (31) | 22 (39) | 0.482 |
NA | 9 (6) | 8 (8) | 1 (1) | |
No. of involved segments | ||||
≥6 | 19 (12) | 13 (13) | 6 (11) | |
<6 | 116 (73) | 72 (70) | 44 (78) | 0.623 |
NA | 24 (15) | 18 (17) | 6 (11) | |
Disease-free interval | ||||
<12 months | 137 (86) | 90 (87) | 47 (84) | |
>12 months | 22 (14) | 13 (13) | 9 (16) | 0.632 |
Mutational status | ||||
RAS/BRAF wt | 91 /(57) | 35 (34) | 56 (100) | |
RAS mut | 57 (36) | 57 (55) | 0 (0) | |
BRAF mut | 6 (4) | 6 (6) | 0 (0) | <0.001 |
NA | 5 (3) | 5 (5) | 0 (0) | |
