Table 2 Histopathologic parameters in the overall population and according to treatment groups
Overall population N (%) | Triplet + bev N (%) | Triplet + cetuximab N (%) | p | |
|---|---|---|---|---|
N = 159 | N = 103 | N = 56 | ||
Resection margins | ||||
R0 | 133 (84) | 84 (82) | 49 (88) | 0.378 |
R1 | 26 (16) | 19 (18) | 7 (14) | |
pCR | ||||
Yes | 8 (5) | 7 (7) | 1 (2) | 0.436 |
No | 151 (95) | 96 (93) | 55 (98) | |
Histopathologic response | ||||
TRG1 | 8 (5) | 7 (7) | 1 (2) | 0.013 |
TRG2 | 33 (21) | 26 (25) | 7 (12) | |
TRG3 | 53 (33) | 33 (32) | 20 (36) | |
TRG4 | 49 (31) | 32 (31) | 17 (30) | |
TRG5 | 16 (10) | 5 (5) | 11 (20) | |
Major response (TRG1–2) | 41 (26) | 33 (32) | 8 (14) | 0.015 |
Partial response (TRG3) | 53 (33) | 33 (32) | 20 (36) | |
No response (TRG4–5) | 65 (41) | 37 (36) | 28 (50) | |
Tumour-normal tissue interface | ||||
<3 mm | 83 (52) | 59 (57) | 24 (43) | 0.082 |
>3 mm | 76/48 | 44 (43) | 32 (57) | |
Necrosis | ||||
Mean | 49 | 49 | 51 | |
≥40% | 27 (17) | 17 (17) | 10 (18) | 0.823 |
<40% | 132 (83) | 86 (83) | 46 (92) | |
Fibrosis | ||||
Mean | 23 | 24 | 20 | |
≥40% | 110 (69) | 72 (70) | 38 (68) | 0.791 |
<40% | 49 (31) | 31 (30) | 18 (32) | |
Infarct-like necrosis | ||||
Yes | 118 (74) | 82 (80) | 36 (64) | 0.035 |
No | 41 (26) | 21 (20) | 20 (36) | |
Lymphocitic infiltration | ||||
Absent | 22 (14) | 16 (16) | 6 (11) | 0.726 |
Mild | 119 (75) | 76 (74) | 43 (78) | |
Moderate | 17 (11) | 11 (10) | 6 (11) | |
Peritumoural inflammatory response | ||||
Mild | 95 (60) | 58 (56) | 37 (66) | 0.373 |
Moderate | 60(38) | 41 (40) | 19 (34) | |
Intense | 2 (1) | 2 (2) | 0 (0) | |
NA | 2 (1) | 2 (2) | 0 (0) | |
Microvescicular steatosis | ||||
Yes | 108 (68) | 73 (71) | 35 (63) | 0.173 |
No | 48 (30) | 27 (26) | 21 (37) | |
NA | 3 (2) | 3 (3) | 0 (0) | |
Macrovescicular steatosis | ||||
Yes | 72 (46) | 44 (43) | 28 (50) | 0.439 |
No | 85 (53) | 57 (55) | 28 (50) | |
NA | 2 (1) | 2 (2) | 0 (0) | |
Sinusoidal dilatation | ||||
0 (absent) | 45 (29) | 28 (28) | 17 (30) | 0.932 |
1 (mild) | 56 (35) | 35 (34) | 21 (38) | |
2 (moderate) | 41 (25) | 28 (27) | 13 (23) | |
3 (severe) | 14 (9) | 9 (8) | 5 (9) | |
NE | 3 (2) | 3 (3) | 0 (0) | |
Parenchimal necrosis | ||||
Yes | 14 (9) | 12 (11) | 2 (4) | 0.140 |
No | 141 (88) | 89 (87) | 52 (93) | |
NE | 4 (3) | 2 (2) | 2 (3) | |
Pericellular fibrosis | ||||
Yes | 20 (12) | 16 (16) | 4 (7) | 0.112 |
No | 136 (86) | 84 (81) | 52 (93) | |
NE | 3 (2) | 3 (3) | 0 (0) | |
