Fig. 3
From: Primary constitutional MLH1 epimutations: a focal epigenetic event
Scatterplot of the normalized mean β-values obtained using the Infinium 450 k Human Methylation array to identify differentially methylated CpG islands and promoters in blood DNA from constitutional MLH1 epimutation carriers against healthy controls a and Lynch syndrome patients with a germline sequence mutation b. The transparency corresponds to point density. One % of the points in the sparsest populated plot regions are drawn explicitly. The colored points represent differentially methylated CpG islands (depicted as arrow #1) and promoters (arrows #2 and #3). FDR adjusted p-values of differentially methylated regions are summarized at the bottom c.
