Fig. 5
From: Primary constitutional MLH1 epimutations: a focal epigenetic event
Representation of differentially methylated region in blood, normal colonic mucosa, and colorectal cancer tissue in constitutional MLH1 epimutation patients a and mutation-positive Lynch syndrome patients b. β-values obtained after global methylation analysis are displayed against CpG sites’ coordinate location. The location of the CpG sites is not drawn to scale. Above, EMP2AIP1-MLH1 CpG island (CI) is represented as black rectangle and their shores are represented in grey. Location of Deng’s promoter regions (DR) are indicated as white rectangles A–D. Genes (G) including displayed CpG sites are represented as grey rectangles. Ensembl GRCh37 was taken as reference for gene coordinates.
