Table 1 Correlation between mutation status and clinical features in conjunctival melanomas
Total | BRAF WT | BRAF V600E | P-value (p < 0.05) | RAS WT | RAS MUT | P-value (p < 0.05) | NF1 WT | NF1 MUT | P-value (p < 0.05) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | (n) | % | (n) | % | (n) | % | (n) | % | (n) | % | (n) | % | (n) | |||||
Total | 63 | 74.6 | 47 | 25.4 | 16 | 81.0 | 51 | 19.0 | 12 | 66.7 | 42 | 33.3 | 21 | |||||
Sex | Female | 50.8 | 32 | 38.1 | 24 | 12.7 | 8 | 0.94 | 44.4 | 28 | 6.3 | 4 | 0.18 | 36.5 | 23 | 14.3 | 9 | 0.37 |
Male | 49.2 | 31 | 36.5 | 23 | 12.7 | 8 | 36.5 | 23 | 12.7 | 8 | 30.2 | 19 | 19 | 12 | ||||
Eye | Right | 55.6 | 35 | 39.7 | 25 | 15.9 | 10 | 0.63 | 42.9 | 27 | 12.7 | 8 | 0.59 | 34.9 | 22 | 20.6 | 13 | 0.52 |
Left | 41.3 | 26 | 31.7 | 20 | 9.5 | 6 | 34.9 | 22 | 6.3 | 4 | 28.6 | 18 | 12.7 | 8 | ||||
N/A | 3.2 | 2 | 3.2 | 2 | 0 | 0 | 3.2 | 2 | 0 | 0 | 3.2 | 2 | 0 | 0 | ||||
TNM | 1 | 55.6 | 35 | 41.3 | 26 | 14.3 | 9 | 0.77 | 44.4 | 28 | 11.1 | 7 | 0.44 | 38.1 | 24 | 17.5 | 11 | 0.56 |
2 | 23.8 | 15 | 17.5 | 11 | 6.3 | 43 | 22.2 | 14 | 1.6 | 1 | 14.3 | 9 | 9.5 | 6 | ||||
3 | 15.9 | 10 | 11.1 | 7 | 4.8 | 0 | 11.1 | 7 | 4.8 | 3 | 9.5 | 6 | 6.3 | 4 | ||||
N/A | 4.8 | 3 | 4.8 | 3 | 0 | 3.2 | 2 | 1.6 | 1 | 4.8 | 3 | 0 | 0 | |||||
Tumour origin | PAM | 52.4 | 33 | 41.3 | 26 | 11.1 | 7 | 0.1 | 44.4 | 28 | 7.9 | 5 | 0.35 | 37.5 | 24 | 14.3 | 9 | 0.43 |
Naevus | 17.5 | 11 | 7.9 | 5 | 9.5 | 6 | 15.9 | 10 | 1.6 | 1 | 11.1 | 7 | 6.3 | 4 | ||||
De novo | 22.2 | 14 | 19 | 12 | 3.2 | 2 | 15.9 | 10 | 4.8 | 4 | 11.1 | 7 | 11.1 | 7 | ||||
N/A | 7.9 | 5 | 6.3 | 4 | 1.6 | 1 | 4.8 | 3 | 3.2 | 2 | 6.3 | 4 | 1.6 | 1 | ||||
Relapses | No | 46 | 29 | 36.5 | 23 | 9.5 | 6 | 0.26 | 33.3 | 21 | 12.7 | 8 | 0.22 | 27 | 17 | 19 | 12 | 0.46 |
Yes | 47.6 | 30 | 31.7 | 20 | 15.9 | 10 | 42.9 | 27 | 4.8 | 3 | 34.9 | 22 | 12.7 | 8 | ||||
N/A | 6.3 | 4 | 6.3 | 4 | 0 | 0 | 4.8 | 3 | 1.6 | 1 | 4.8 | 3 | 1.6 | 1 | ||||
Metastasis | No | 68.3 | 43 | 49.2 | 31 | 19.0 | 12 | 0.32 | 54.0 | 34 | 14.3 | 9 | 0.34 | 42.9 | 27 | 25.4 | 16 | 0.55 |
Yes | 22.2 | 14 | 15.9 | 10 | 6.3 | 4 | 20.6 | 13 | 1.6 | 1 | 17.5 | 11 | 4.8 | 3 | ||||
N/A | 9.5 | 6 | 9.5 | 6 | 0 | 0 | 6.3 | 4 | 3.2 | 2 | 6.3 | 4 | 3.2 | 2 | ||||
Exenteration | No | 76.2 | 48 | 57.1 | 36 | 19.0 | 12 | 0.36 | 60.3 | 38 | 15.9 | 10 | 0.64 | 47.6 | 30 | 28.6 | 18 | 0.44 |
Yes | 17.5 | 11 | 11.1 | 7 | 6.3 | 4 | 15.9 | 10 | 1.6 | 1 | 14.3 | 9 | 3.2 | 2 | ||||
N/A | 6.3 | 4 | 6.3 | 4 | 0 | 0 | 4.8 | 3 | 1.6 | 1 | 4.8 | 3 | 1.6 | 1 | ||||
Age at diagnose | Median 67.4 years , Range 40.1–88.8 years | |||||||||||||||||
