Table 2 MAP kinase pathway activating mutations in conjunctival melanoma

BRAF

All mutations

16

25

V600E

16

25

RAS

All mutations

12

19

NRAS

Q61R

5

8

Q61K

2

3

Q61H

1

2

Q61L

1

2

G13D

1

2

G12N, G12C

1

2

KRAS

G12A

1

2

NF1

All mutations

21

33

T60del

1

2

R262C

1

2

C42Y, G2397R, S2587L

1

2

S2751N, L552P, G2392E

1

2

D176E

2

3

L847P, P866S, V1762I

1

2

C1899Y

1

2

M1180I, S52F; T60I

1

2

A2715V; A2208T

1

2

G2397R, R2517fs

1

2

I1824fs

1

2

L1892^a

1

2

N1451L

1

2

Q1815^a

1

2

Q756fs

1

2

R1362^a

1

2

R440^a, Q2239^a; S1497F; V1393A

1

2

S168L

1

2

S1786^a, L1102^a; Q1815fs

1

2

Y1678fs

1

2

Wild type

14

22

Total

63