Table 2 MYCN data for disseminated tumour cells in the bone marrow and tumour material from relapse or progression
From: Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
Pt. no. | Age at dx in months | INSS stage at dx | MNA in BM-DTCs at dx | Relapse/progression | Time to relapse/progression in years | Analysed relapse/progression material | MNA in relapse/progression |
|---|---|---|---|---|---|---|---|
33 | 12 | 2a | No | No | — | — | — |
39 | 13 | 4 | No | No | — | — | — |
41 | 13 | 3a | No | No | — | — | — |
58 | 19 | 4 | hetMNA | Yes | 1 | na | — |
63 | 23 | 4 | hetMNA | Yes | 0, 7 | na | — |
66 | 26 | 4 | hetMNAb | Yes | 0, 8 | na | — |
82 | 46 | 4 | hetMNAc | Yes | 1 | Liquor | hetMNAd |
84 | 46 | 4 | No | Yes | 2, 4 | DTCs | No |
86 | 50 | 4 | No | Yes | 0, 3 | na | — |
89 | 57 | 4 | No | Yes | 1, 9 | na | — |
90 | 61 | 4 | ne | Yes | 7, 10, 11 | Metastases | 1. rel: hetMNA; 2. rel: no MNA; 3. rel: no MNA |
97 | 93 | 4 | No | Yes | 2, 5 | DTCs | No |
99 | 171 | 4 | No | Yes | 0, 7 | Tumour | No |
11 | 5 | 4s | No BM infiltration | Yes | 2, 1 | Tumour | MNA |
48 | 14 | 3 | No BM infiltration | Yes | 1, 2 | Tumour | No |
77 | 41 | 2 | No BM infiltration | Yes | 0, 3 | Tumour | No |
78 | 42 | 4 | No BM infiltration | Yes | 0, 5 | Lung metastasis | No |
