Table 2 Correlations between serum MMP-8 levels, markers of systemic inflammation and the density of tumour-infiltrating inflammatory cells

From: High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer

 

Unadjusted

Adjusted

Pearson r

p Value

β

p Value

Systemic inflammatory markers

 Serum C-reactive protein

0.324

5.9E–8

0.220

2.3E–4

 Serum albumin

−0.203

0.001

−0.130

0.026

 Blood neutrophil/lymphocyte ratio

0.436

6.8E–14

0.379

3.0E–11

 Blood neutrophil count

0.467

5.9E–16

0.399

1.9E–12

 Blood lymphocyte count

−0.099

0.106

−0.080

0.167

Tumour-infiltrating immune cells

 CD3 IM

−0.162

0.008

−0.045

0.461

 CD3 CT

−0.067

0.268

0.020

0.745

 CD3 IEL

−0.068

0.267

0.024

0.696

 CD8 IM

−0.073

0.233

0.030

0.616

 CD8 CT

−0.067

0.272

0.014

0.818

 CD8 IEL

−0.024

0.701

0.060

0.327

 FoxP3 IM

−0.198

0.001

−0.071

0.267

 FoxP3 CT

−0.187

0.002

−0.060

0.358

 CD68 IM

−0.075

0.221

−0.001

0.980

 CD68 CT

0.009

0.884

0.071

0.223

 Mast cell tryptase IM

−0.245

4.6E–5

−0.167

0.005

 Mast cell tryptase CT

−0.179

0.003

−0.149

0.010

 Neutrophil elastase IM

−0.099

0.109

−0.009

0.794

 Neutrophil elastase CT

−0.025

0.688

0.008

0.894

  1. The correlations were adjusted for tumour stage variables (T1–2 vs. T3–4; N0 vs. N1–2; M0 vs. M1), patient age and patient gender by multiple linear regression.
  2. CT centre of tumour, IEL intraepithelial, IM invasive margin
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