Table 1 Cohort characteristics of BRCA1/2 mutations carriers
From: Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers
BRCA1 (n = 1550) | BRCA2 (n = 964) | BRCA1/2 combined (n = 2514) | ||||
|---|---|---|---|---|---|---|
BC+a | BC−a | BC+a | BC−a | BC+a | BC−a | |
n (%) | 630 (40.7) | 920 (59.3) | 308 (31.9) | 656 (68.1) | 938 (37.3) | 1576 (62.7) |
Data source, n (%) | ||||||
HEBON | 629 (99.8) | 913 (99.2) | 308 (100) | 639 (97.4) | 937 (99.9) | 1552 (98.5) |
HEBON + PGD: | ||||||
PGD < HEBON | 1 (0.2) | 2 (0.2) | 0 (0.0) | 5 (0.8) | 1 (0.1) | 7 (0.4) |
PGD > HEBON | 0 (0.0) | 1 (0.1) | 0 (0.0) | 4 (0.6) | 0 (0.0) | 5 (0.3) |
PGD only | 0 (0.0) | 4 (0.4) | 0 (0.0) | 8 (1.2) | 0 (0.0) | 12 (0.8) |
Age at censoring (years) (%) | ||||||
Mean age at censoring (SD) | 40.1 (8.5) | 43.1 (11.6) | 44.4 (8.9) | 44.6 (12.0) | 41.5 (8.9) | 43.7 (11.8) |
<35 | 176 (27.9) | 247 (26.9) | 36 (11.7) | 149 (22.7) | 212 (22.6) | 396 (25.1) |
35–44 | 276 (43.8) | 259 (28.2) | 132 (42.9) | 190 (29.0) | 408 (43.5) | 449 (28.5) |
45–64 | 175 (27.8) | 384 (41.7) | 139 (45.1) | 276 (42.1) | 314 (33.5) | 660 (41.9) |
65+ | 3 (0.5) | 30 (3.3) | 1 (0.3) | 41 (6.3) | 4 (0.4) | 71 (4.5) |
Censoring reason | ||||||
Baseline Q/PGD contact | 0 (0.0) | 561 (61.0) | 0 (0.0) | 429 (65.4) | 0 (0.0) | 990 (62.8) |
Breast cancer | 630 (100) | 0 (0.0) | 308 (100) | 0 (0.0) | 938 (100) | 0 (0.0) |
Other cancer | 0 (0.0) | 90 (9.8) | 0 (0.0) | 73 (11.1) | 0 (0.0) | 163 (10.3) |
BPM | 0 (0.0) | 269 (29.2) | 0 (0.0) | 154 (23.5) | 0 (0.0) | 423 (26.8) |
Birth year (%) | ||||||
1940–1957 | 244 (38.7) | 216 (23.5) | 153 (49.7) | 191 (29.1) | 397 (42.3) | 407 (25.8) |
1958–1968 | 231 (36.7) | 296 (32.2) | 101 (32.8) | 189 (28.8) | 332 (35.4) | 485 (30.8) |
1969–1993 | 155 (24.6) | 408 (44.4) | 54 (17.5) | 276 (42.1) | 209 (22.3) | 684 (43.4) |
IVF (%) | ||||||
No | 616 (97.8) | 889 (96.6) | 305 (99.0) | 624 (95.1) | 921 (98.2) | 1513 (96.0) |
Yes | 12 (1.9) | 29 (3.2) | 3 (1.0) | 32 (4.9) | 15 (1.6) | 61 (3.9) |
Missing | 2 (0.3) | 2 (0.2) | 0 (0.0) | 0 (0.0) | 2 (0.2) | 2 (0.1) |
