Table 3 IVF exposure and breast cancer risk in BRCA1 mutation carriers
From: Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers
BC+a | BC−a | HR (95% CI)b | |
|---|---|---|---|
n = 1550 | 630 (40.7) | 920 (59.4) | |
IVF treatment | |||
No | 616 (97.8) | 889 (96.6) | 1.00 |
Yes | 12 (1.9) | 29 (3.2) | 1.12 (0.60–2.09) |
Missing | 2 (0.3) | 2 (0.2) | |
Age at first IVF (%)c | |||
Median (min–max, years) | 31.1 (23–36) | 32.3 (24–42) | |
No IVF | 616 (97.8) | 889 (96.6) | 1.00 |
≤32 years | 7 (1.1) | 14 (1.5) | 1.91 (0.88–4.16) |
>32 years | 5 (0.8) | 15 (1.6) | 0.70 (0.28–1.76) |
Missing | 2 (0.3) | 2 (0.2) | |
Time since first IVF treatment (%)c | |||
No IVF | 616 (97.8) | 889 (96.6) | 1.00 |
<5 years ago started | 6 (1.0) | 13 (1.4) | 1.15 (0.49–2.66) |
≥5 years ago started | 6 (1.0) | 16 (1.7) | 1.10 (0.47–2.56) |
Missing | 2 (0.3) | 2 (0.2) | |
Time since last IVF treatment (%)c | |||
No IVF | 616 (97.8) | 889 (96.6) | 1.00 |
<2 years ago stopped | 5 (0.8) | 7 (0.8) | 1.49 (0.60–3.73) |
≥2 years ago stopped | 5 (0.8) | 21 (2.3) | 0.84 (0.33–2.10) |
Age of last treatment before censoring unknown | 2 (0.3) | 1 (0.1) | |
Missing | 2 (0.3) | 2 (0.2) | |
