Table 2 Biomarker expression according to morphological subtype
From: Transcription factors WT1 and p53 combined: a prognostic biomarker in ovarian cancer
A. p53 status according to morphological subtype | ||||
|---|---|---|---|---|
Subtype histoscore (area × intensity)a | N | Abnormal loss (N) (%) p53 = 0 | Normal p53 (N) (%) p53>0.1<2.25 | Abnormal uniform stain (N) (%) p53 = 2.25–2.7 |
Borderline serous | 29 | 3 (10.3%) | 26 (89.7%) | 0 |
Type 1 serous | 9 | 2 (22.2%) | 5 (55.6%) | 2 (22.2%) |
Type 2 serous | 64 | 7 (10.90%) | 19 (29.7%) | 38 (59.4%) |
Borderline mucinous | 18 | 10 (50%) | 9 (45%) | 1 (5%) |
Type 1 mucinous | 14 | 4 (22.2%) | 12 (66.7%) | 2 (11.1%) |
Borderline mixed epithelial | 1 | 0 | 1 (100%) | 0 |
Type 1 mixed epithelial | 4 | 0 | 1 (25%) | 3 (50%) |
Type 2 mixed epithelial | 4 | 0 | 0 | 4 (100%) |
Type 1 endometrioid | 6 | 3 (50%) | 3 (50%) | 0 |
Type 2 endometrioid | 25 | 6 (24%) | 10 (40%) | 9 (36%) |
Type 2 carcinosarcoma | 3 | 0 | 1 (33.3%) | 2 (66.7%) |
Type 1 clear cell | 14 | 0 | 13 (92.9%) | 1 (7.1%) |
B. WT1 status according to morphological subtype | |||
|---|---|---|---|
Subtype | N | WT1− (N) (%) | WT1+ (N) (%) |
Borderline serous | 28 | 2 (7.1%) | 26 (92.9%) |
Type 1 serous | 9 | 7 (77.8%) | 2 (22.2%) |
Type 2 serous | 64 | 5 (7.8%) | 59 (92.8%) |
Borderline mucinous | 20 | 20 (100%) | 0 |
Type 1 mucinous | 18 | 16 (88.9%) | 2 (11.1%) |
Borderline mixed epithelial | 1 | 1 (100%) | 0 |
Type 1 mixed epithelial | 4 | 2 (50%) | 2 (50%) |
Type 2 mixed epithelial | 4 | 0 | 4 (100%) |
Type 1 endometrioid | 6 | 5 (83.3%) | 1 (16.7%) |
Type 2 endometrioid | 25 | 9 (36%) | 16 (64%) |
Type 2 carcinosarcoma | 3 | 1 (33.3%) | 2 (66.7%) |
Type 1 clear cell | 14 | 13 (92.9%) | 1 (7.1%) |
