Table 2 Association between ctDNA detection and clinical features in patients with Ewing sarcoma and osteosarcoma

From: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group

 

ctDNA positive

ctDNA negative

p value

Ewing sarcoma (n = 94)

Full cohort

49 (52.1)

45 (47.9)

 

Initial diagnosis (n = 77)

41 (53.3)a

36 (46.8)

0.79

Relapse (N = 17)

8 (47.1)

9 (52.9)

 

Initial diagnosis (n = 77)

 Age (mean, 95% CI)

13.4 (12.1–14.8)

13.3 (11.8–14.8)

0.85

 Male

23 (54.8)

19 (45.2)

0.82

 Female

18 (51.4)

17 (48.6)

 

 Metastatic

18 (69.2)

8 (30.8)

0.053

 Non-metastatic

22 (44.0)

28 (56.0)

 

 Pelvic primary

12 (66.7)

6 (33.3)

0.18

 Non-pelvic primary

25 (46.3)

29 (53.7)

 

Tumour size <8 cm

5 (33.3)

10 (66.7)

0.063

Tumour size ≥8 cm

5 (83.3)

1 (16.7)

 

Osteosarcoma (n = 72)

Full cohort

41 (56.9)

31 (43.1)

 

 Age (mean, 95% CI)

14.0 (12.9–15.2)

12.9 (11.4–14.3)

0.2

 Male

25 (54.4)a

21 (45.7)

0.63

 Female

16 (61.5)

10 (38.5)

 

 Femur primary

22 (71.0)

9 (29.0)

0.054

 Other primary

19 (46.3)

22 (53.7)

 
  1. aPercentages do not equal 100% due to rounding
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