Fig. 1 | British Journal of Cancer

Fig. 1

From: Hierarchical clustering of activated proteins in the PI3K and MAPK pathways in ER-positive, HER2-negative breast cancer with potential therapeutic consequences

Fig. 1

Hierarchical clustering of seven proteins in ER-positive, HER2-negative tumours visualised in a heatmap. Red bars indicate a higher score in activation. Blue bars indicate a lower score and, therefore, less activation of the corresponding protein. The red box classifies the patients in group A with a more activated PI3K and/or MAPK pathway, while the black box identifies patients in group N in whom these pathways are grossly not activated. p-ERK1/2 phosphorylated extracellular signal-regulated kinase 1 and 2; p-S6RP phosphorylated 40S ribosomal protein S6; p-p70S6K phosphorylated p70 ribosomal protein S6 kinase; p-AKT phosphorylated AKT at phospho-sites Thr308 and Ser473; p-4EBP1 initiation factor eukaryotic initiation factor 4E binding protein 1; PTEN phosphatase and tensin homologue

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