Table 1 Patient characteristics for 1-year testicular germ cell cancer survivors treated between 1976 and 2007 with primary surgery with/without radiotherapy
From: Risk of diabetes after para-aortic radiation for testicular cancer
Patient characteristic | Base cohort | Subcohorta | Diabetes after TC | |||
|---|---|---|---|---|---|---|
N | % | N | % | N | % | |
All patients | 2998 | 614 | 161 | |||
Histology | ||||||
Seminoma | 2071 | 69.1 | 414 | 67.4 | 131 | 81.4 |
Non-seminoma | 927 | 30.9 | 200 | 32.6 | 30 | 18.6 |
Age at testicular cancer, years | ||||||
Median±IQR | 33.3 | 27.9–39.0 | 33.3 | 28.0–39.0 | 37.4 | 32.1–42.0 |
<30 | 1012 | 33.8 | 213 | 34.7 | 28 | 17.4 |
30–40 | 1349 | 45.0 | 271 | 44.1 | 73 | 45.3 |
40–50 | 637 | 21.3 | 130 | 21.2 | 60 | 37.3 |
Treatment period | ||||||
1976–1985 | 477 | 15.9 | 93 | 15.2 | 63 | 39.1 |
1986–1995 | 916 | 30.6 | 216 | 35.2 | 50 | 31.1 |
1995–2007 | 1605 | 53.5 | 305 | 49.7 | 48 | 29.8 |
Follow-up duration, years | ||||||
Median±IQR | 13.4 | 8.3–20.5 | 14.6 | 9.6–21.3 | 14.3 | 8.9–21.1 |
0–4 years | 153 | 5.2 | 43 | 7.0 | 18 | 11.2 |
5–9 years | 641 | 21.4 | 126 | 20.5 | 36 | 22.4 |
10–14 years | 738 | 24.6 | 149 | 24.3 | 34 | 21.1 |
15–19 years | 578 | 19.3 | 107 | 17.4 | 23 | 14.3 |
20–24 years | 434 | 14.5 | 101 | 16.5 | 24 | 14.9 |
25–29 years | 243 | 8.1 | 52 | 8.5 | 16 | 9.9 |
≥30 years | 211 | 7.0 | 36 | 5.9 | 10 | 6.2 |
Relapse, % yes | 79 | 2.6 | 30 | 4.9 | 3 | 1.9 |
Treatment for TC (total treatment) | ||||||
Hemi-orchidectomy only | — | — | 208 | 33.9 | 28 | 17.4 |
Radiotherapy | — | — | 406 | 66.1 | 133 | 82.6 |
RT field | ||||||
No PAO/ DL radiotherapyb | — | — | 208 | 33.9 | 28 | 17.4 |
Radiotherapy, PAO | — | — | 164 | 26.7 | 39 | 24.2 |
Radiotherapy, DL | — | — | 229 | 37.3 | 87 | 54.0 |
Unknown | — | — | 13 | 2.1 | 7 | 3.7 |
Prescribed PAO-radiation dose | ||||||
No PAO radiotherapy b | — | — | 208 | 33.9 | 28 | 17.4 |
<26 Gray | — | — | 86 | 14.0 | 34 | 21.1 |
26–32 Gray | — | — | 233 | 38.0 | 69 | 42.9 |
≥32 Gray | — | — | 48 | 7.8 | 17 | 10.6 |
Dose unknown | — | — | 26 | 4.2 | 6 | 3.7 |
Field unknown | — | — | 13 | 2.1 | 7 | 4.3 |
Median dose (IQR) | 26 | 26-26 | 26 | 25-30 | ||
Cardiovascular disease risk factors | ||||||
BMI at TC diagnosis | ||||||
<30 kg/m2 | — | — | 215 | 35.0 | 57 | 34.4 |
≥30 kg/m2 | — | — | 21 | 3.4 | 15 | 9.3 |
Unknown | — | — | 378 | 61.6 | 89 | 55.3 |
Diabetes, % yesc | 39 | 6.4 | 161 | 100 | ||
Diabetes type | ||||||
Insulin dependent | — | — | 3 | 7.7 | 24 | 14.9 |
Non-Insulin dependent | — | — | 32 | 82.0 | 123 | 76.4 |
Unknown type or treatment | — | — | 4 | 10.3 | 14 | 8.7 |
Hypercholesterolemia at TC diagnosis | ||||||
Yes | — | — | 5 | 0.8 | 3 | 1.9 |
No | — | — | 574 | 93.5 | 141 | 87.6 |
Unknown | — | — | 35 | 5.7 | 17 | 10.6 |
Hypertension at TC diagnosis | ||||||
Yes | — | — | 10 | 1.6 | 9 | 5.6 |
No | — | — | 568 | 92.5 | 136 | 84.5 |
Unknown | — | — | 36 | 5.9 | 16 | 9.9 |
Smoking status at TC diagnosis | ||||||
Yes | — | — | 181 | 29.5 | 55 | 34.2 |
No | — | — | 229 | 37.3 | 74 | 46.0 |
Unknown | — | — | 204 | 33.2 | 32 | 19.9 |
Vital status at date of last contact | ||||||
Alive | 2884 | 95.6 | 587 | 95.6 | 135 | 83.9 |
Died | 97 | 3.2 | 22 | 3.6 | 26 | 16.2 |
Emigrated | 37 | 1.2 | 5 | 0.8 | 0 | 0 |
Age at end of follow-up | ||||||
Median±IQR | 48.2 | 40.9–55.7 | 47.4 | 39.7–54.7 | 51.9 | 45.1–59.2 |
