Table 3 Associations between pre-diagnostic levels of serum cytokines and risk of brain cancer among active component military personnel
Cytokine | Quartiles of cytokine concentration | ||||||
|---|---|---|---|---|---|---|---|
Q1a | Q2 | Q3 | Q4 | P b | P c | ||
IL-12p40 | HRd | 1.00 | 1.06 | 1.12 | 1.19 | 0.333 | 0.285 |
95% CI | 0.79, 1.42 | 0.81, 1.57 | 0.83, 1.70 | ||||
IL-15 | HR | 1.00 | 0.83 | 0.73 | 0.55 | 0.002 | 0.001 |
95% CI | 0.63, 1.09 | 0.53, 1.00 | 0.38, 0.80 | ||||
IL-16 | HR | 1.00 | 0.89 | 0.71 | 0.62 | 0.001 | 0.004 |
95% CI | 0.68, 1.15 | 0.53, 0.94 | 0.46, 0.84 | ||||
IL-7 | HR | 1.00 | 0.95 | 1.18 | 1.18 | 0.155 | 0.198 |
95% CI | 0.72, 1.26 | 0.89, 1.58 | 0.86, 1.62 | ||||
MCP1 | HR | 1.00 | 0.87 | 0.90 | 0.79 | 0.231 | 0.148 |
95% CI | 0.66, 1.15 | 0.65, 1.22 | 0.56, 1.11 | ||||
TARC | HR | 1.00 | 1.25 | 1.04 | 1.09 | 0.883 | 0.421 |
95% CI | 0.93, 1.68 | 0.76, 1.41 | 0.77, 1.54 | ||||
PLGF | HR | 1.00 | 0.95 | 0.96 | 1.04 | 0.844 | 0.698 |
95% CI | 0.71, 1.26 | 0.70, 1.32 | 0.72, 1.50 | ||||
VEGF | HR | 1.00 | 1.25 | 1.42 | 1.14 | 0.417 | 0.317 |
95% CI | 0.92, 1.70 | 1.02, 1.98 | 0.80, 1.62 | ||||
IFNg | HR | 1.00 | 1.00 | 1.06 | 1.08 | 0.771 | 0.120 |
95% CI | 0.78, 1.29 | 0.81, 1.39 | 0.76, 1.40 | ||||
IL-10 | HR | 1.00 | 1.03 | 0.87 | 0.73 | 0.033 | 0.067 |
95% CI | 0.78, 1.37 | 0.64, 1.17 | 0.52, 1.01 | ||||
IL-8 | HR | 1.00 | 1.18 | 0.95 | 0.98 | 0.559 | 0.727 |
95% CI | 0.88, 1.58 | 0.69, 1.30 | 0.71, 1.35 | ||||
TNFa | HR | 1.00 | 1.08 | 1.10 | 1.09 | 0.656 | 0.291 |
95% CI | 0.81, 1.43 | 0.81, 1.50 | 0.78, 1.50 | ||||
HGF | HR | 1.00 | 0.82 | 0.87 | 0.80 | 0.228 | 0.584 |
95% CI | 0.63, 1.06 | 0.66, 1.15 | 0.58, 1.10 | ||||
TGFb1 | HR | 1.00 | 1.34 | 1.35 | 1.38 | 0.080 | 0.049 |
95% CI | 1.03, 1.74 | 1.01, 1.82 | 0.99, 1.92 | ||||
