Table 4 Associations between pre-diagnostic levels of serum cytokines and risk of adult brain cancer among active component military personnel overall and according to diagnosis of immune-related condition

Cytokine	Overall		Immune-related condition				P ^d
	Overall		No		Yes
	Case-control	HR^a	Case-control	HR	Case-control	HR
	N^b	95% CI	N^c	95% CI	N^c	95% CI
IL-12p40	455	1.06	242	1.08	59	1.70	0.475
IL-12p40		1.00, 1.12		0.93, 1.25		1.13, 2.54
IL-15	455	0.83	242	0.87	59	0.64	0.0009
IL-15		0.74, 0.94		0.75, 1.02		0.42, 0.99
IL-16	450	0.85	239	0.85	58	0.70	0.031
IL-16		0.77, 0.94		0.75, 0.96		0.54, 0.90
IL-7	454	1.08	241	1.09	59	1.42	0.310
IL-7		0.97, 1.19		0.96, 1.25		1.03, 1.96
MCP1	453	0.94	240	0.94	59	0.70	0.063
MCP1		0.84, 1.04		0.82, 1.08		0.49, 0.99
TARC	448	1.01	237	1.03	58	0.87	0.809
TARC		0.90, 1.13		0.89, 1.19		0.60, 1.28
PLGF	454	1.01	243	1.08	59	0.62	0.045
PLGF		0.90, 1.14		0.93, 1.26		0.42, 0.89
VEGF	452	1.05	242	1.09	59	0.91	0.636
VEGF		0.94, 1.18		0.94, 1.27		0.66, 1.26
IFNg	451	1.01	241	0.99	57	1.19	0.395
IFNg		0.92, 1.12		0.87, 1.12		0.87, 1.62
IL-10	381	0.89	176	0.88	45	0.91	0.152
IL-10		0.80, 0.99		0.77, 1.01		0.66, 1.24
IL-8	378	0.97	194	0.92	50	0.74	0.880
IL-8		0.88, 1.08		0.81, 1.06		0.53, 1.02
TNFa	434	1.02	228	1.01	57	0.85	0.827
TNFa		0.92, 1.14		0.87, 1.17		0.66, 1.10
HGF	454	0.94	243	0.97	59	0.83	0.178
HGF		0.85, 1.04		0.85, 1.11		0.61, 1.13
TGFb1	452	1.10	242	1.15	59	0.96	0.155
TGFb1		0.99, 1.23		0.99, 1.32		0.68, 1.34

HR hazard ratio, 95% CI 95% confidence interval
^aAll hazard ratios are adjusted for type of military service and represent change in risk per quartile increase in cytokine concentration
^bTotal number of case-control pairs included in the analysis
^cNumber of informative case-control pairs included in the analysis
^dAll hazard ratios are adjusted for type of military service and represent change in risk per quartile increase in cytokine concentration

Quick links

Search