Table 6 Associations between serum levels of pre-diagnostic cytokines and risk of adult brain cancer among active component military personnel according to age at cancer diagnosis

From: Serially measured pre-diagnostic levels of serum cytokines and risk of brain cancer in active component military personnel

Cytokine

 

Age at diagnosis (years)

P a

≤35

>35

IL-12p40

HRb

1.03

1.15

0.222

95% CI

0.89, 1.20

0.94, 1.40

 

IL-15

HR

0.89

0.72

0.002

95% CI

0.77, 1.04

0.58, 0.90

 

IL-16

HR

0.82

0.88

0.064

95% CI

0.72, 0.93

0.75, 1.04

 

IL-7

HR

1.11

1.02

0.831

95% CI

0.98, 1.25

0.85, 1.22

 

MCP1

HR

0.93

0.98

0.731

95% CI

0.81, 1.06

0.81, 1.19

 

TARC

HR

1.13

0.90

0.121

95% CI

0.99, 1.30

0.74, 1.08

 

PLGF

HR

1.02

0.99

0.986

95% CI

0.88, 1.18

0.80, 1.22

 

VEGF

HR

1.04

1.04

0.559

95% CI

0.90, 1.21

0.85, 1.26

 

IFNg

HR

1.02

1.06

0.895

95% CI

0.90, 1.15

0.89, 1.27

 

IL-10

HR

0.92

0.85

0.055

95% CI

0.81, 1.04

0.70, 1.03

 

IL-8

HR

0.97

0.96

0.212

95% CI

0.85, 1.10

0.80, 1.14

 

TNFa

HR

1.05

0.98

0.730

95% CI

0.91, 1.21

0.83, 1.16

 

HGF

HR

1.01

0.82

0.019

95% CI

0.89, 1.14

0.68, 0.99

 

TGFb1

HR

1.10

1.11

0.334

95% CI

0.96, 1.25

0.91, 1.36

 
  1. HR hazard ratio, 95% CI 95% confidence interval
  2. aP value for heterogeneity of quartile cytokine trends by age
  3. bAll hazard ratios are adjusted for type of military service and represent change in risk per quartile increase in cytokine concentration
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