Fig. 3 | British Journal of Cancer

Fig. 3

From: WT1 expression in vessels varies with histopathological grade in tumour-bearing and control tissue from patients with breast cancer

Fig. 3

WT1 expression drops as histopathological grade increases in human breast cancers. Grade I tumours expressed more WT1+ cells than Grade II cancers, but no difference was otherwise detected between tumour Grades (a). Grade I tumours expressed more CD31-positive cells than with Grade III cancers (b), alongside more cells that co-expressed WT1 and CD31 when compared to both Grade II and Grade III tumours (c). The number of vessels was higher in Grade I versus Grade III tumours (d) and there were more WT1-positive vessels in Grade I tumours compared with both Grade II and Grade III tumours (e). The percentage of WT1-positive vessels within the tumours appeared to decrease as histopathological Grade increased, and this was significant when Grade I cancers were compared with Grade III (f). Data are mean ± standard (where n = 8 Grade I, 17 Grade II, 29 Grade III, deviation); (*p < 0.05, **p < 0.01 and ***p < 0.005 by unpaired Student’s t-test)

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