Fig. 4
From: Teaching an old dog new tricks: next-generation CAR T cells
Schematic representation of selected strategies to inhibit CAR T cell activation and prevent off tumour on target activity. Strategies to enhance CAR T cell safety include: a drug-inducible CAR T cells, b CAR T cells that require antigen-specific antibodies (CD16/FITC or Uni-CAR T cells) and c inhibitory CARs (iCARs), which moderate or inhibit T cell activation when antigens expressed on bystander cells are encountered. Legend indicated in the figure
