Fig. 1
High ascites mtDNA levels are associated with reduced progression-free survival following primary surgery. a–c High ascites levels of mtDNA, but not gDNA, are associated with reduced median PFS. Banked ascites supernatants from patients with newly diagnosed advanced EOC were analysed for mtDNA and gDNA. a Variability exists between ascites mtDNA (ng/μL) levels as measured by qPCR (n = 68). b High mtDNA levels as defined by the upper 75th quartile (red line) are associated with reduced PFS as compared to the lowest 75th quartile (black line) of mtDNA (n = 68, log-rank, p = 0.0178). c Ascites gDNA levels are not associated with PFS (n = 62, log-rank, p = 0.839)
