Table 2 Ascites neutrophil elastase stratified into low, intermediate, and high levels predicts reduced progression-free survival within 12 months following surgery

From: Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer

 

Neutrophil Elastase Level

<377 ng/mL

377 < ng/mL <1222

>1122 ng/mL

p value

N

11

52

10

 

Age, Mean

65.3

61.4

62.7

ns

Stage (% IV)

9%

23%

10%

ns

Grade (% 3)

81%

76%

21%

ns

Debulking (% Optimal)

36%

23%

13%

ns

Progression-free survival

    

  Events

9

49

9

 

  Median PFS [95% CI]

16.26 [5.88-NA]

9.56 [6.51-15.0]

5.57 [0.29-NA]

0.0328

  PFS to 12 months (std. error)

0.70 (0.144)

0.42 (0.069)

0.20 (0.127)

 < 0.001

  PFS to 24 months (std. error)

0.12 (0.109)

0.10 (0.044)

0.10 (0.095)

ns

  HR (PFS)

0.41

1

2.05

0.0367

  Adj HRa

0.36

1

2.94

0.039

  1. aAdjusted for Age, stage, grade, debulking status
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