Fig. 5 | British Journal of Cancer

Fig. 5

From: (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations

Fig. 5

(P)RR silencing attenuates growth and Wnt/β-catenin signalling of CRC xenografts in vivo. a Tumour formation of scrambled shRNA- and (P)RR shRNA-transfected DLD-1 cells at day 21 after subcutaneous transplantation into nude mice (n = 6). Successful (P)RR silencing was confirmed by western blotting before cell transplantation. b Growth patterns of tumour volume during 21 days. c Tumour weights at day 21. d Representative IHC images of (P)RR, active β-catenin and c-Myc staining in xenograft tumour tissues. Black arrow: staining of active β-catenin translocated into nuclei. Numerical data are presented as mean ± SEM. *P < 0.05 vs. scrambled shRNA group

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