Table 2 Seropositivity to individual sexually transmitted infections and risk of ovarian cancer: results from the NHS and NHSII

	Control, n	All cases					Borderline ovarian tumours			Invasive EOC			Invasive serous EOC
		Unadjusted			Adjusted^a		Adjusted^a			Adjusted^a			Adjusted^a
		Case, n	RR	95% CI	RR	95% CI	Case, n	RR	95% CI	Case, n	RR	95% CI	Case, n	RR	95% CI
C. trachomatis
Negative	297	271	Ref.		Ref.		63	Ref.		208	Ref.		135	Ref.
Positive	40	66	2.04	1.26–3.29	2.07	1.25–3.43	17	2.11	1.04–4.28	49	1.98	1.21–3.23	35	2.31	1.33–4.01
M. genitalium
Negative	328	320	Ref.		Ref.		74	Ref.		246	Ref.		164	Ref.
Positive	9	17	2.00	0.86–4.67	1.92	0.78–4.72	6	2.75	0.86–8.76	11	1.81	0.68–4.77	6	1.59	0.51–4.98
Herpes simplex virus, type 2
Negative	308	299	Ref.		Ref.		68	Ref.		231	Ref.		152	Ref.
Positive	29	38	1.36	0.81–2.28	1.38	0.79–2.42	12	2.04	0.92–4.54	26	1.24	0.69–2.26	18	1.32	0.68–2.59
HPV16 E6 or HPV18 E6+E7 or HPV45 E6+E7
Negative	330	326	Ref.		Ref.		77	Ref.		249	Ref.		164	Ref.
Positive	7	11	1.57	0.61–4.05	1.23	0.44–3.44	3	2.03	0.47–8.77	8	1.37	0.47–3.99	6	1.84	0.58–5.88

CI confidence interval, EOC epithelial ovarian cancer, HPV human papillomavirus, NHS Nurses’ Health Study, RR relative risk
^aConditional logistic regression models for all cases; all other results are from unconditional logistic regression models additionally controlling for matching factors (year of birth (±1 year), menopausal status at diagnosis (premenopausal, postmenopausal, unknown), and factors at one or both blood draws: menopausal status (premenopausal, postmenopausal, unknown), month of collection (±1 month), time of day (±2 h), fasting status (>8, ≤8 h), and postmenopausal hormone use (yes/no). Premenopausal NHSII cases and controls additionally matched on luteal day at blood collection (date of next menstrual cycle minus date of blood draw, ±1 day)). All adjusted models adjusted for: parity (nulliparous, 1 pregnancy, 2 pregnancies, 3 pregnancies, 4+ pregnancies), oral contraceptive use (never, <1 year, 1–5 years, 5+ years), tubal ligation (yes, no), marital status (never, married/domestic partnership/living with partner, divorced/separated, widowed), and weight change between ages 18 years and blood collection (kg, continuous)

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