Table 3 Cross-classification of seropositivity to C. trachomatis and other sexually transmitted infections and risk of ovarian cancer: results from the NHS and NHSII

	Control, n	All cases			Invasive EOC
		Case, n	RR^a	95% CI	Case, n	RR^a	95% CI
C. trachomatis (CT) and M. genitalium (MG)
CT− and MG−	291	263	Ref.		203	Ref.
CT+ and MG−	37	57	1.89	1.11–3.20	43	1.79	1.08–2.97
CT− and MG+	6	8	1.12	0.34–3.74	5	0.93	0.26–3.31
CT+ and MG+	3	9	4.38	1.03–18.56	6	5.74	1.23–26.72
CT and herpes simplex virus, type 2 (HSV2)
CT− and HSV2−	276	253	Ref.		197	Ref.
CT+and HSV2−	32	46	1.85	1.06–3.24	34	1.67	0.97–2.87
CT− and HSV2+	21	18	1.01	0.50–2.03	11	0.73	0.33–1.62
CT+ and HSV2+	8	20	2.90	1.14–7.37	15	3.26	1.25–8.51
CT and HSV and MG
CT− and HSV2− and MG−	272	245	Ref.		192	Ref.
CT+ and HSV2− and MG−	30	41	1.77	0.98–3.18	32	1.64	0.94–2.85
CT− and (HSV2+ or MG+)	25	26	1.19	0.63–2.23	16	0.90	0.45–1.81
CT+ and (HSV2+ or MG+)	10	25	3.04	1.29–7.21	17	3.25	1.33–7.96
CT and HSV and MG and human papillomavirus (HPV) 16 E6, HPV18 E6+E7, or HPV45 E6+E7
Negative for all	270	237	Ref.		186	Ref.
CT+ only	29	41	1.88	1.03–3.42	32	1.73	0.99–3.03
MG+, HSV2+ or HPV+ only	27	34	1.34	0.80–2.24	22	1.19	0.64–2.24
CT+ and any other infection	11	25	2.74	1.20–6.27	17	3.01	1.26–7.18

CT and HPV combination not evaluated, 0 cases and 3 controls positive for both infections
CI confidence interval, EOC epithelial ovarian cancer, NHS Nurses’ Health Study, RR relative risk
^aConditional logistic regression models for all cases; all other results are from unconditional logistic regression models additionally controlling for matching factors (year of birth (±1 year), menopausal status at diagnosis (premenopausal, postmenopausal, unknown), and factors at one or both blood draws: menopausal status (premenopausal, postmenopausal, unknown), month of collection (±1 month), time of day (±2 h), fasting status (>8, ≤8 h), and postmenopausal hormone use (yes/no). Premenopausal NHSII cases and controls additionally matched on luteal day at blood collection (date of next menstrual cycle minus date of blood draw, ±1 day)). All adjusted models adjusted for: parity (nulliparous, 1 pregnancy, 2 pregnancies, 3 pregnancies, 4 + pregnancies), oral contraceptive use (never, <1 year, 1–5 years, 5+ years), tubal ligation (yes, no), marital status (never, married/domestic partnership/living with partner, divorced/separated, widowed), and weight change between ages 18 years and blood collection (kg, continuous)

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